ABL1 gene plays a role in cancer and in a developmental disorder
Articles / cardiovascular disease / Genetics

ABL1 gene plays a role in cancer and in a developmental disorder

The human gene ABL1 is well-known for its association with cancer. In this case, a piece of chromosome 9 containing the ABL1 gene and a piece of chromosome 22 break off and switch places. The ABL1 gene fuses with the BCR gene in chromosome 22, which is then called the Philadelphia chromosome. Bone marrow cells … Continue reading

New insights from an autoimmunity-mediated atherosclerosis mouse model could pave the way to new therapies for cardiovascular diseases
Articles / autoimmunity / Heart Disease

New insights from an autoimmunity-mediated atherosclerosis mouse model could pave the way to new therapies for cardiovascular diseases

By Ana María Rodríguez, Ph.D. Patients with autoimmune disease have a higher risk of developing atherosclerosis and cardiovascular disease. Although studies have shown that human atherosclerotic plaques typically have antibodies against self-antigens, the role those complexes or immune cells play in the development of atherosclerotic lesions is still under investigation. To study how autoimmunity may lead … Continue reading