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Follistatin: a key player in embryo implantation
Articles / Fertility

Follistatin: a key player in embryo implantation

The complex process of embryo implantation in the uterus has raised interest among researchers in the field in part because it fails in about half of in vitro fertilization procedures. Looking to improve the success rate of assisted reproductive technologies, researchers at Baylor College of Medicine investigated in more detail the mechanism involved in successful … Continue reading

Image of the Month: Mechanisms of cancer survival
Articles

Image of the Month: Mechanisms of cancer survival

  Among other studies, the  lab of Dr. Chonghiu Cheng is pioneering research projects to better undertsand the role alternative splicing plays in cancer. “We have been intrigued by the fact that nearly all human genes are detected to undergo alternative splicing, vastly expanding the human proteomes. Despite these important observations, alternative splicing in cancer has remained … Continue reading

What activates the PI3K pathway, the most commonly mutated pathway in cancer that can be targeted by drugs?
Articles / Cancer pathways

What activates the PI3K pathway, the most commonly mutated pathway in cancer that can be targeted by drugs?

The PI3K pathway has a number of diverse functions, including altering the cell’s metabolism and driving cell growth and proliferation. The PI3K pathway also is the most commonly mutated pathway in cancer that can be targeted by drugs. “Our multi-institutional research team studied the PI3K pathway, one of the most important pathways of the cell,” … Continue reading

A new HER2 mutation leads to a clinical trial and to a promising diagnostic tool for metastatic breast cancer
Articles / Metastatic breast cancer

A new HER2 mutation leads to a clinical trial and to a promising diagnostic tool for metastatic breast cancer

There is a group of metastatic breast cancers that has the HER2 gene amplified – the cells have many copies of it – which leads to enhanced activity of the product enzyme, a tyrosine kinase. HER2 has been established as a therapeutic target in breast cancer, and breast cancers in which the HER2 gene is … Continue reading

CD44s, not CD44v, contributes to cancer survival
Articles / cancer survival

CD44s, not CD44v, contributes to cancer survival

Cells may stray away from their normal function in a number of ways. For example, it’s been known for some time that in a number of cancers the surface molecule CD44 seems to be involved with cancer-promoting mechanisms. Studies trying to discover how this happens, however, have yielded controversial results. In her lab, Dr. Chonghui … Continue reading