Researchers perform 3-D genome surgery on female’s silent X chromosome
Articles / Genetics / structural biology

Researchers perform 3-D genome surgery on female’s silent X chromosome

Females have two X chromosomes in each of their cells. Fully unfolded, each copy is two inches long. One of these two X chromosomes is inactive – its genes are turned off. This copy folds into a structure called the Barr body, a mysterious configuration that was discovered in 1949. Recently, scientists have shown that … Continue reading

Crystal structure of PKGI suggests a new activation mechanism
Articles / Biochemistry / Heart Disease / structural biology

Crystal structure of PKGI suggests a new activation mechanism

By Ana María Rodríguez, Ph.D. Kinases form a large family of proteins that seem to be involved in nearly every aspect of cell life. Faulty protein kinases have been found in a number of human conditions, including cardiovascular diseases, cancer and diabetes, and this has triggered much interest in understanding their regulatory mechanisms in order … Continue reading