Image of the Month: Human natural killer cells preparing to deliver a lethal strike to diseased cells
immunology

Image of the Month: Human natural killer cells preparing to deliver a lethal strike to diseased cells

This mosaic montage of still images of live natural killer (NK) cells from the human immune system shows the cells have a skeleton of microtubules seen here in green fluorescent color. NK cells, the first responders to viral infections, use this cytoskeleton to mobilize and deliver the toxic content of lytic vesicles (here colored in … Continue reading

Genomic approaches can provide answers to undiagnosed primary immunodeficiency diseases.
Articles / Genetic sequencing / immunology

Genomic approaches can provide answers to undiagnosed primary immunodeficiency diseases.

Lea este artículo en español, aquí. An international team of physician-researchers set out to change the approach by which they genetically diagnose primary immunodeficiency diseases (PIDDs). This work represents a potential landmark in the field because of the extent of how genomics is interwoven with the clinical approach to the patient. PIDDs range from severe … Continue reading

Targeting B-cell malignancies with κ-specific T cells can lead to complete clinical responses
Articles / Cancer / immunology

Targeting B-cell malignancies with κ-specific T cells can lead to complete clinical responses

Treating cancer with the patient’s own immune cells has been successful. In particular, treating B cell malignancies with the patients’ own immune T cells modified so that they target specific B cell markers present on malignant B cells. However, if T cells remain present in the body for prolonged periods of time, which might be … Continue reading

The mTOR pathway: a new avenue for breast cancer cells to promote tumor growth
Articles / Cancer / immunology

The mTOR pathway: a new avenue for breast cancer cells to promote tumor growth

Cancer cells respond in various ways to the body’s attempts to eliminate them. One strategy is to recruit immune cells in the body, such as the myeloid-derived suppressor cells (MDSCs), which are involved in the suppression of the body’s response against tumors. “There are alternative paths a tumor may take without the MDSCs, but those … Continue reading

Discovery of CTLA-4 in dendritic cells opens new possibilities to fight cancer
Cancer / immunology

Discovery of CTLA-4 in dendritic cells opens new possibilities to fight cancer

By Ana María Rodríguez, Ph.D. In the battle against cancer, T cells are the ‘foot soldiers’ and dendritic cells are ‘the generals.’ Cancer cells are not passive players in these encounters, they can fight the foot soldiers back by pushing a brake on the T cells that will turn them off. This ‘brake’ is a … Continue reading

STAT6 may explain mortality associated with some asthma drugs
Asthma / immunology

STAT6 may explain mortality associated with some asthma drugs

By Ruth SoRelle, M.P.H. The “black box” warning on some long-acting beta agonists – drugs used to ward off asthma attacks – mandates that such medications be sold as combination agents that contain a steroid to prevent the rare episodes of medication-associated deaths. Large studies of populations of people on these drugs have showed a … Continue reading