Together, DAG1 and Yap ‘hit the brakes’ on heart cell proliferation
Articles / Heart Disease

Together, DAG1 and Yap ‘hit the brakes’ on heart cell proliferation

Although both are known to play a role in cardiac function and previous work had hinted that they might interact with each other, it was not clear that the dystrophin glycoprotein complex (DGC) pathway and the Hippo pathway worked together to affect heart cell proliferation. The James Martin lab at Baylor College of Medicine explored … Continue reading

New insights from an autoimmunity-mediated atherosclerosis mouse model could pave the way to new therapies for cardiovascular diseases
Articles / autoimmunity / Heart Disease

New insights from an autoimmunity-mediated atherosclerosis mouse model could pave the way to new therapies for cardiovascular diseases

By Ana María Rodríguez, Ph.D. Patients with autoimmune disease have a higher risk of developing atherosclerosis and cardiovascular disease. Although studies have shown that human atherosclerotic plaques typically have antibodies against self-antigens, the role those complexes or immune cells play in the development of atherosclerotic lesions is still under investigation. To study how autoimmunity may lead … Continue reading

Crystal structure of PKGI suggests a new activation mechanism
Articles / Biochemistry / Heart Disease / structural biology

Crystal structure of PKGI suggests a new activation mechanism

By Ana María Rodríguez, Ph.D. Kinases form a large family of proteins that seem to be involved in nearly every aspect of cell life. Faulty protein kinases have been found in a number of human conditions, including cardiovascular diseases, cancer and diabetes, and this has triggered much interest in understanding their regulatory mechanisms in order … Continue reading

Articles / Heart Disease / Public Health

Appropriate use of aspirin for heart health evaluated

Best viewed in Chrome, Firefox or Safari By Graciela Gutierrez Many people have taken to heart the advice to take an aspirin a day to help prevent heart attacks – maybe too much so. When researchers at Baylor College of Medicine and the Michael E. DeBakey Veterans Affairs Medical Center reviewed a nationwide sample of … Continue reading

Heart injury marker can identify varying risks of blood pressure
Articles / Biomarkers / Heart Disease

Heart injury marker can identify varying risks of blood pressure

By Graciela Gutierrez For years, physicians have used troponin T as evidence of the kind of heart damage that results from heart attack. Now, however, a consortium of researchers, including those from Baylor College of Medicine and the Michael E. DeBakey Veterans Affairs Medical Center in Houston have found a new value in measuring levels … Continue reading