How do muscles grow up? Check alternative splicing
Articles / Genetics / muscular disorders

How do muscles grow up? Check alternative splicing

Growing up is a complex affair, even for muscles. In the mouse, for instance, newborn muscles grow into adult muscles within the first three weeks after birth. This transition allows a newborn mouse with limited ability to move to become an agile, fast-moving creature. During this transition, some of the newborn muscle proteins are replaced by adult … Continue reading

A pill to prevent Alzheimer’s disease might someday be a reality
Alzheimer's disease / Articles / Genetics

A pill to prevent Alzheimer’s disease might someday be a reality

Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer’s disease, according to scientists at Baylor College of Medicine, Texas Children’s Hospital and Johns Hopkins University School of Medicine. The scientists took a three-pronged approach to help subdue early events that occur in the brain long before … Continue reading

Improving the view on the genetic causes of retinitis pigmentosa
Articles / Genetics / Retinitis pigmentosa

Improving the view on the genetic causes of retinitis pigmentosa

Progressive development of night blindness and tunnel vision, sometimes from the early age of 2, are trademarks of retinitis pigmentosa. Being the most common inherited disorder of the retina, retinitis pigmentosa affects nearly 1 in 4,000 people. More than 1 million are visually impaired around the world due to this untreatable disease. A number of … Continue reading

“Freeze-frame” synthetic proteins capture DNA events leading to cancer
Articles / Cancer / Genetics

“Freeze-frame” synthetic proteins capture DNA events leading to cancer

Cancer scientists have focused on identifying signature genetic changes present in cancerous cells and understanding how these changes lead to cancer. Although this approach has delivered important advances, at Baylor College of Medicine Dr. Susan Rosenberg and colleagues wanted to get closer look at how these changes happen. “In my lab we study how the … Continue reading

Image of the Month: Neuron-muscle synapses in the fruit fly
Articles / Genetics / Neuroscience

Image of the Month: Neuron-muscle synapses in the fruit fly

Certain human gene variants of ATAD3A can cause rare neurological syndromes characterized by global developmental delay, low muscular tone and visual, neurological and heart problems. The association between gene variants of ATAD3A and the neurological conditons was established using a combination of patients’ whole-exome sequencing studies led by Dr. Tamar Harel and Dr. James R. Lupski, … Continue reading

Mouse Gata2 gene can affect female fertility and uterine susceptibility to cancer
Articles / Fertility / Genetics

Mouse Gata2 gene can affect female fertility and uterine susceptibility to cancer

Determining the cause of infertility can be a complex matter. Infertility may be the result of a problem in one or several of the multiple steps involved in the process that leads to pregnancy. In the United States, according to the Centers for Disease Control and Prevention, as many as 7.5 million women 15 to … Continue reading

How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer
Articles / Cancer / Genetics

How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer

[See video below] “People may think of lung cancer as one disease, but lung cancer is a collection of diverse subtypes of cells and each subtype may respond differently to the same therapy,” said Dr. Chad Creighton, associate professor of medicine and member of the Dan L Duncan Comprehensive Cancer Center Division of Biostatistics at … Continue reading