Surviving bodily defenses: human rotavirus manipulates immune response to maintain infection
Articles / Gastrointestinal diseases / rotavirus

Surviving bodily defenses: human rotavirus manipulates immune response to maintain infection

The gut of a child infected with rotavirus is like a battleground. On one side, the virus invades the epithelial cells that form the lining of the small intestine. The virus replicates driving havoc in the intestinal environment, which causes severe diarrhea, vomiting, fever and abdominal pain. Dehydration usually follows and, unless the child is … Continue reading

Researchers seek to make mini-guts that mimic life
Gastrointestinal diseases / Public Health

Researchers seek to make mini-guts that mimic life

By Ruth SoRelle, M.P.H. A five-year, $5.1 million National Institutes of Health grant will help researchers from Baylor College of Medicine, Rice University and the University of Texas MD Anderson Cancer Center engineer better “mini-guts” that are physiologically active. This grant will also allow engineering of the these cultures to mimic the stretch and pull … Continue reading

A bacterial signal activates the immune system against rotavirus
Articles / Gastrointestinal diseases / Infectious diseases / Public Health

A bacterial signal activates the immune system against rotavirus

A bacterial signal activates the immune system against rotavirus By Ruth SoRelle, M.P.H. For three decades, Dr. Mary Estes, professor of molecular virology and microbiology at Baylor College of Medicine has studied the important rotavirus in her laboratory, seeking ways to fight the gastrointestinal disease that causes severe dehydration and roughly half a million deaths … Continue reading