‘Listening’ to single cells may uncover cancer origins
Articles / Cancer

‘Listening’ to single cells may uncover cancer origins

Listening to a single voice in a crowd can be difficult. In a similar way, determining gene expression in single cells has posed quite a challenge.  A major step toward single-cell analysis can potentially help scientists study how cancerous tumors begin, which could lead to better treatments, diagnosis and prevention in the future. “Cancer begins with … Continue reading

Image of the Month: Lighting up blood vessels in a tumor
Articles / Cancer

Image of the Month: Lighting up blood vessels in a tumor

When a mouse breast tumor is exposed to radio frequency (RF) electric fields the interaction between RF electric fields and the cancer tissue causes tumor vessels to dilate and open up. The network of blood vessels in the tumor can be seen with a fluorescence microscope when injecting fluorescent quantum dots (green) that lit up as they flow … Continue reading

“Freeze-frame” synthetic proteins capture DNA events leading to cancer
Articles / Cancer / Genetics

“Freeze-frame” synthetic proteins capture DNA events leading to cancer

Cancer scientists have focused on identifying signature genetic changes present in cancerous cells and understanding how these changes lead to cancer. Although this approach has delivered important advances, at Baylor College of Medicine Dr. Susan Rosenberg and colleagues wanted to get closer look at how these changes happen. “In my lab we study how the … Continue reading

How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer
Articles / Cancer / Genetics

How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer

[See video below] “People may think of lung cancer as one disease, but lung cancer is a collection of diverse subtypes of cells and each subtype may respond differently to the same therapy,” said Dr. Chad Creighton, associate professor of medicine and member of the Dan L Duncan Comprehensive Cancer Center Division of Biostatistics at … Continue reading

Targeting two cell surface molecules can mitigate escape of solid glioblastoma tumors
Articles / Cancer / immunotherapy

Targeting two cell surface molecules can mitigate escape of solid glioblastoma tumors

One strategy to fight cancer cells involves ‘training’ the individual’s own immune system to fight the tumor, what is called immunotherapy. One form of immunotherapy involves ‘teaching’ the immune cells to recognize molecules on the cancer cell surface in ways that would lead to tumor destruction or better tumor control. Which cell surface molecules to … Continue reading

Altered metabolism in castration-resistant prostate cancer may point to new therapies
Articles / Cancer / metabolism

Altered metabolism in castration-resistant prostate cancer may point to new therapies

Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant — it is able to grow without androgen, a lethal condition. Researchers from Baylor College of Medicine and University of Michigan, along with collaborators in other … Continue reading

Chromosome remodeler SETD2 also remodels the cytoskeleton in kidney cancer cells
Articles / Cancer / epigenetics

Chromosome remodeler SETD2 also remodels the cytoskeleton in kidney cancer cells

Kidney cancer begins when certain genes mutate and, as a result, alter how key molecules work. One of these key molecules is SETD2, which is known as a chromosome remodeler, that is, one that helps turn genes on in the nucleus of the cell. When researchers discovered that kidney cells that lose SETD2 become cancerous, … Continue reading