Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB
Articles / brain cancer

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side effects, including psychiatric disorders, growth retardation and cognitive impairment. Sonic Hedgehog, one of the four biologically distinct subtypes of medulloblastoma, is named after the cellular pathway that is impaired in … Continue reading

DNA loops matter for NFIA gene expression in brain tumors
Articles / brain cancer

DNA loops matter for NFIA gene expression in brain tumors

The nuclear factor I-A (NFIA) gene is important for both normal brain development and brain tumor growth. One way to discover paths that can lead to brain malignancy is to first better understand the process of normal brain development. The Deneen lab has followed this strategy. They have studied the mechanisms by which normal brain … Continue reading