Mouse model shows that Notch activation can drive metastatic prostate cancer
Articles / Metastasis / prostate cancer

Mouse model shows that Notch activation can drive metastatic prostate cancer

Nearly 200 thousand men are diagnosed with prostate cancer every year. Most of the deaths associated with prostate cancer occur in advanced stages of the disease, which are the result of metastasis – the spreading of the tumor away from its origin. Notch signaling pathway is involved in prostate cancer and, in a paper published … Continue reading

Through the looking glass, fluorescent signals reveal the workings of a fly’s brain
Articles / Neuroscience

Through the looking glass, fluorescent signals reveal the workings of a fly’s brain

Bain activity is fast. Millisecond fast. When a person, a mouse or a fly sees an object, neurons in their brains display a flurry of electrical and chemical activity to communicate with each other in a fraction of a second.  The brain has to be fast to help organisms make sense of their environments, escape … Continue reading

Gene TMEM230 suggests a novel mechanism for Parkinson’s disease
Articles / Neuroscience / Parkinson's disease

Gene TMEM230 suggests a novel mechanism for Parkinson’s disease

In the United States, Parkinson’s disease – the second most common neurodegenerative disorder without effective treatment – affects about 1 percent of the population older than 60 years of age. Most of the cases do not run in families, but the rare cases of familial Parkinson’s disease have contributed to a better understanding of the illness, as … Continue reading

Targeting B-cell malignancies with κ-specific T cells can lead to complete clinical responses
Articles / Cancer / immunology

Targeting B-cell malignancies with κ-specific T cells can lead to complete clinical responses

Treating cancer with the patient’s own immune cells has been successful. In particular, treating B cell malignancies with the patients’ own immune T cells modified so that they target specific B cell markers present on malignant B cells. However, if T cells remain present in the body for prolonged periods of time, which might be … Continue reading

A single species of gut bacteria can reverse autism-related social behavior in mice
Articles / behavior / diet / Microbiome / Prenatal

A single species of gut bacteria can reverse autism-related social behavior in mice

The absence of one specific species of gut bacteria causes social deficits in mice. Researchers at Baylor College of Medicine report June 16 in Cell that by adding this bacterial species back to the guts of affected mice, the researchers were able to reverse some of the mice’s behavioral deficits, which are reminiscent of symptoms … Continue reading

Twinning linked to genes tied to reproductive fitness traits
Articles / Genetics

Twinning linked to genes tied to reproductive fitness traits

Bearing fraternal twins, or dizygotic (DZ) twinning, runs in families, is potentially influenced by more than one gene and linked to a maternal factor. In a study published in the American Journal of Human Genetics, an international team reports the finding of two genes that are associated with increased odds for women bearing fraternal twins. … Continue reading

The mTOR pathway: a new avenue for breast cancer cells to promote tumor growth
Articles / Cancer / immunology

The mTOR pathway: a new avenue for breast cancer cells to promote tumor growth

Cancer cells respond in various ways to the body’s attempts to eliminate them. One strategy is to recruit immune cells in the body, such as the myeloid-derived suppressor cells (MDSCs), which are involved in the suppression of the body’s response against tumors. “There are alternative paths a tumor may take without the MDSCs, but those … Continue reading