Bacteria and mitochondria have a common language
Articles / Microbiome

Bacteria and mitochondria have a common language

It’s not news that microbes can alter the physiology of the organisms in which they live, but the actual molecular mechanisms that mediate their interactions have been largely unknown. Understanding how microbes and their hosts influence each other’s functions is one of the interests of Dr. Meng Wang. “Microbes living inside another organism, the host, … Continue reading

‘Silent seizures’ discovered in patients with Alzheimer’s disease
Alzheimer's disease / seizures

‘Silent seizures’ discovered in patients with Alzheimer’s disease

Deep in the brains of two patients with Alzheimer’s disease, the main memory structure, the hippocampus, displays episodic seizure-like electrical activity. These nonconvulsive hippocampal seizures are the first signs of ‘silent’ brain electrical network dysfunction described in patients with Alzheimer’s disease, a condition affecting more than 5 million people in the U.S. “About 10 years … Continue reading

‘MARRVEL’: a new way to compile big data in a human-centric way
Articles / Gene variants database search

‘MARRVEL’: a new way to compile big data in a human-centric way

When a group of researchers in the Undiagnosed Disease Network at Baylor College of Medicine realized they were spending days combing through databases searching for information regarding gene variants, they decided to do something about it. They created MARRVEL (Model organism Aggregated Resources for Rare Variant ExpLoration) to help not only their own lab but … Continue reading

It’s all connected: circadian clock, microbiome and response to diet
Articles / circadian clock / Microbiome

It’s all connected: circadian clock, microbiome and response to diet

Disrupt the circadian clock, and metabolism will change. Alter the microbiome and, again, metabolism will change. Would altering the circadian clock affect the microbiome? Dr. Derek O’Neil, a postdoctoral fellow in obstetrics and gynecology at Baylor College of Medicine took on the project to answer this question and he found the first evidence that a … Continue reading

Out of the body and into bone-in culture: new technique tests drugs for metastatic cancer
Articles / breast cancer / Metastasis

Out of the body and into bone-in culture: new technique tests drugs for metastatic cancer

For many cancer patients, the problem is metastasis – the dissemination of tumor cells to other organs – after the primary tumor has been eliminated. Metastases, however, tend to respond differently than the primary tumor to the treatment in part due to residing in a different organ with a different microenvironment. Recreating biological microenvironments in … Continue reading

Sometimes, scientists solve medical mysteries in a day’s work
Articles / Human genetics

Sometimes, scientists solve medical mysteries in a day’s work

It all began on a Thursday, the day Dr. Daryl Scott goes to clinic to visit patients. One of the patients was a young male with intellectual disability, developmental delay, macrocephaly (enlarged head) and very flexible joints. The genetics lab indicated that the patient did not seem to have any known genetic changes that could explain … Continue reading