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Primate study sheds light on human developmental disorders
Articles / Neuroscience

Primate study sheds light on human developmental disorders

We are now closer to better understanding brain disorders such as autism and schizophrenia. In a recent paper published in Nature, scientists have elucidated the genetic programs that guide the formation and development of specific regions within the brain of rhesus monkeys. Dr. Ed Lein, investigator at the Allen Institute for Brain Sciences in Seattle, … Continue reading

Altered metabolism in castration-resistant prostate cancer may point to new therapies
Articles / Cancer / metabolism

Altered metabolism in castration-resistant prostate cancer may point to new therapies

Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant — it is able to grow without androgen, a lethal condition. Researchers from Baylor College of Medicine and University of Michigan, along with collaborators in other … Continue reading

Narrowing down genes involved in male fertility
Articles / Fertility / Genetics

Narrowing down genes involved in male fertility

A couple’s fertility depends on both the female’s and male’s ability to reproduce, which relies on thousands of genes working properly. Around the world, infertility affects about 15 percent of couples and approximately 10 percent of men who are attempting to sire offspring. “Infertility is a serious condition and many of the genes responsible for … Continue reading

Researchers perform 3-D genome surgery on female’s silent X chromosome
Articles / Genetics / structural biology

Researchers perform 3-D genome surgery on female’s silent X chromosome

Females have two X chromosomes in each of their cells. Fully unfolded, each copy is two inches long. One of these two X chromosomes is inactive – its genes are turned off. This copy folds into a structure called the Barr body, a mysterious configuration that was discovered in 1949. Recently, scientists have shown that … Continue reading

Study identifies a new rare genetic syndrome associated with severe infections and lung disease in infants
Articles / Genetics / lungs

Study identifies a new rare genetic syndrome associated with severe infections and lung disease in infants

An international team of researchers has identified a new rare genetic condition – a chromosome breakage syndrome associated with severe infections and lung disease in infants. The discovery provides an explanation for this deadly pulmonary disease, possibilities to diagnose it and opportunities for developing alternate ways to treat it. The results appear July 18 in … Continue reading

Chromosome remodeler SETD2 also remodels the cytoskeleton in kidney cancer cells
Articles / Cancer / epigenetics

Chromosome remodeler SETD2 also remodels the cytoskeleton in kidney cancer cells

Kidney cancer begins when certain genes mutate and, as a result, alter how key molecules work. One of these key molecules is SETD2, which is known as a chromosome remodeler, that is, one that helps turn genes on in the nucleus of the cell. When researchers discovered that kidney cells that lose SETD2 become cancerous, … Continue reading

A new experimental system sheds light on how memory loss may occur
Articles / Memory / Neuroscience

A new experimental system sheds light on how memory loss may occur

Two interconnected brain areas – the hippocampus and the entorhinal cortex – help us to know where we are and to remember it later.  It is still not clear, however, how these two regions work together to allow us find our way back to a familiar place. To answer that question, researchers at Baylor College … Continue reading