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Together, DAG1 and Yap ‘hit the brakes’ on heart cell proliferation
Articles / Heart Disease

Together, DAG1 and Yap ‘hit the brakes’ on heart cell proliferation

Although both are known to play a role in cardiac function and previous work had hinted that they might interact with each other, it was not clear that the dystrophin glycoprotein complex (DGC) pathway and the Hippo pathway worked together to affect heart cell proliferation. The James Martin lab at Baylor College of Medicine explored … Continue reading

A 12-hour biological clock coordinates essential bodily functions
Articles / Biological clocks

A 12-hour biological clock coordinates essential bodily functions

It’s not a good idea to disturb the circadian rhythm on a regular basis. For instance, experimental evidence shows that night-shift workers who periodically change their night and day shifts or people who travel overseas often alter their sleep cycles, and this seems to make them prone to gain weight and develop diabetes and other … Continue reading

Follistatin: a key player in embryo implantation
Articles / Fertility

Follistatin: a key player in embryo implantation

The complex process of embryo implantation in the uterus has raised interest among researchers in the field in part because it fails in about half of in vitro fertilization procedures. Looking to improve the success rate of assisted reproductive technologies, researchers at Baylor College of Medicine investigated in more detail the mechanism involved in successful … Continue reading

Image of the Month: Mechanisms of cancer survival
Articles

Image of the Month: Mechanisms of cancer survival

  Among other studies, the  lab of Dr. Chonghiu Cheng is pioneering research projects to better undertsand the role alternative splicing plays in cancer. “We have been intrigued by the fact that nearly all human genes are detected to undergo alternative splicing, vastly expanding the human proteomes. Despite these important observations, alternative splicing in cancer has remained … Continue reading

What activates the PI3K pathway, the most commonly mutated pathway in cancer that can be targeted by drugs?
Articles / Cancer pathways

What activates the PI3K pathway, the most commonly mutated pathway in cancer that can be targeted by drugs?

The PI3K pathway has a number of diverse functions, including altering the cell’s metabolism and driving cell growth and proliferation. The PI3K pathway also is the most commonly mutated pathway in cancer that can be targeted by drugs. “Our multi-institutional research team studied the PI3K pathway, one of the most important pathways of the cell,” … Continue reading