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“Freeze-frame” synthetic proteins capture DNA events leading to cancer
Articles / Cancer / Genetics

“Freeze-frame” synthetic proteins capture DNA events leading to cancer

Cancer scientists have focused on identifying signature genetic changes present in cancerous cells and understanding how these changes lead to cancer. Although this approach has delivered important advances, at Baylor College of Medicine Dr. Susan Rosenberg and colleagues wanted to get closer look at how these changes happen. “In my lab we study how the … Continue reading

How breast cancer can become resistant to hormone therapy
Articles / Breast cancer resistance

How breast cancer can become resistant to hormone therapy

Despite the overall success of hormone therapy, breast cancer tumors in patients with metastatic disease often fail to respond. One new mechanism that can explain resistance to hormone therapy in breast cancer involves two significant changes in the cells – overexpression of the FOXA1 gene and increased production of IL-8. A cluster of breast cancer … Continue reading

New mutations in gene PKD1L1 are associated with disarrangement of human internal organs
Articles / Human genetics

New mutations in gene PKD1L1 are associated with disarrangement of human internal organs

Scientists have linked gene PKD1L1 with disarrangement of human internal organs, known as laterality defects, and complex congenital heart disease. This discovery contributes to a better understanding of the genetic causes of this condition and opens the possibility for families carrying the disease genes to have children unaffected by the disease via prenatal or pre-implantation … Continue reading

Image of the Month: Human natural killer cells preparing to deliver a lethal strike to diseased cells
immunology

Image of the Month: Human natural killer cells preparing to deliver a lethal strike to diseased cells

This mosaic montage of still images of live natural killer (NK) cells from the human immune system shows the cells have a skeleton of microtubules seen here in green fluorescent color. NK cells, the first responders to viral infections, use this cytoskeleton to mobilize and deliver the toxic content of lytic vesicles (here colored in … Continue reading

Mouse Gata2 gene can affect female fertility and uterine susceptibility to cancer
Articles / Fertility / Genetics

Mouse Gata2 gene can affect female fertility and uterine susceptibility to cancer

Determining the cause of infertility can be a complex matter. Infertility may be the result of a problem in one or several of the multiple steps involved in the process that leads to pregnancy. In the United States, according to the Centers for Disease Control and Prevention, as many as 7.5 million women 15 to … Continue reading

How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer
Articles / Cancer / Genetics

How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer

[See video below] “People may think of lung cancer as one disease, but lung cancer is a collection of diverse subtypes of cells and each subtype may respond differently to the same therapy,” said Dr. Chad Creighton, associate professor of medicine and member of the Dan L Duncan Comprehensive Cancer Center Division of Biostatistics at … Continue reading