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Transcribing the rules for brain circuitry
Articles / Neuroscience

Transcribing the rules for brain circuitry

By Graciela Gutierrez Billions of neurons in the brain are linked through trillions of synaptic connections, and although disentangling this wiring may seem like mission impossible, a research team from Baylor College of Medicine took on the task. Researchers worked to decipher the wiring of the mouse neocortex, the outermost part of the brain that … Continue reading

Missing “copy” of Jag1 gene results in mouse model for Alagille syndrome
Articles

Missing “copy” of Jag1 gene results in mouse model for Alagille syndrome

By Julia Parsons  When mice usually used in studies of genetic disease lack a copy of the jagged gene (Jag1), they have many of the characteristics, including bile duct abnormalities, of human Alagille syndrome, a developmental disorder characterized by bile duct and cardiovascular defects, as well as abnormalities in other organs, reported Baylor College of … Continue reading

Normal levels of “Goldilocks” protein in mouse model restores neurologic function in MECP2 duplication syndrome
Articles

Normal levels of “Goldilocks” protein in mouse model restores neurologic function in MECP2 duplication syndrome

By Ruth SoRelle, M.P.H. For 15 years and more, Dr. Huda Zoghbi, professor of molecular and human genetics at Baylor College of Medicine, and director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and her team have worked with the “Goldilocks” protein, MeCP2. Too little of the protein results in Rett … Continue reading

The writhing and coiling of DNA drives cell activity
Articles

The writhing and coiling of DNA drives cell activity

By Ruth SoRelle, M.P.H. Using a multidisciplinary approach, researchers, led by those at Baylor College of Medicine, revealed in unprecedented detail the three-dimensional structure of biologically active DNA. A report on their work appears online in the journal Nature Communications. “The beautiful double-helical structure we all know and love is not the actual active form of … Continue reading

Image of the Month: Organizing DNA
Articles

Image of the Month: Organizing DNA

A multi-institutional team spanning Baylor College of Medicine, Rice University, Stanford University, and the Broad Institute of MIT and Harvard has reported the first successful surgery to change how the genome is folded inside the nucleus — an advance that may help scientists better understand genetic disease. Last year, researchers at Baylor College of Medicine’s … Continue reading